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Related Experiment Videos

Effect of glucagon on digital circulation.

G E Burch, T D Giles

    Clinical Pharmacology and Therapeutics
    |April 1, 1975
    PubMed
    Summary

    Glucagon initially constricts digital blood vessels, including arteries, veins, and shunts. A late response involves vessel reopening, though some shunts may remain constricted, suggesting vasoactive substance release.

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    Area of Science:

    • Cardiovascular Physiology
    • Endocrinology

    Background:

    • Glucagon's role in peripheral circulation is not fully understood.
    • Investigating glucagon's effects on digital blood flow is crucial for understanding its systemic impact.

    Purpose of the Study:

    • To investigate the acute effects of intra-arterial glucagon on digital circulation.
    • To characterize the temporal response of digital arteries, veins, and arterio-venous (A-V) shunts to glucagon.

    Main Methods:

    • Seven subjects underwent continuous digital rheoplethysmography (RPG).
    • Glucagon (0.1–2.0 mg) was infused into the brachial artery of the studied extremity.
    • Rheoplethysmograms were recorded to assess digital vascular responses.

    Main Results:

    • Intra-arterial glucagon induced an initial maximal constriction of digital arteries, veins, and A-V shunts within 8–27 seconds.
    • A late response showed reopening of arteries and veins.
    • Persistent constriction of A-V shunts was observed in some subjects.

    Conclusions:

    • Glucagon exerts biphasic effects on digital circulation: initial vasoconstriction followed by vasodilation.
    • The late vasodilation may involve local release of vasoactive substances, similar to reactive hyperemia.
    • Persistent A-V shunt constriction suggests a specific regulatory mechanism by glucagon.

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