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Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death
09:18

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death

Published on: December 27, 2016

CD47 and death signaling in the immune system

R D Pettersen1

  • 1Department of Pediatric Research, The National Hospital, Oslo, Norway. rolf.pettersen@klinmed.uio.no

Apoptosis : an International Journal on Programmed Cell Death
|March 3, 2001
PubMed

Insights

The study explores CD47, an immune cell surface antigen, as a potential death receptor. It suggests CD47 may trigger a unique apoptosis pathway, impacting immune response and lymphocyte growth.

Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Biology

Background:

  • Receptor-mediated cell death is crucial for immune system regulation and T cell-mediated cytotoxicity.
  • Beyond the tumor necrosis factor receptor family, other cell surface antigens are being investigated for their role in immune apoptotic signaling.

Purpose of the Study:

  • To investigate the role of the Ig family member CD47 in lymphocyte apoptosis.
  • To explore CD47 as a potential death receptor mediating non-classical apoptosis.
  • To review current knowledge on immune system death control.

Main Methods:

  • Literature review focusing on CD47 function in lymphocytes.
  • Analysis of data implicating CD47 in growth regulation and apoptotic signaling.
  • Synthesis of information on immune cell death pathways.

Main Results:

  • CD47, an Ig family member, demonstrates a functional role in lymphocyte growth regulation.
  • Evidence suggests CD47 mediates cell death through a non-classical apoptosis pathway.
  • CD47 is proposed as a novel death receptor candidate in lymphocytes.

Conclusions:

  • CD47 warrants further investigation as a key player in immune cell death signaling.
  • Understanding CD47's apoptotic function could offer new insights into immune regulation.
  • This review highlights the evolving landscape of death receptor research in immunology.

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