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Innate and acquired resistance to African trypanosomiasis.

S J Black1, J R Seed, N B Murphy

  • 1Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst 01003, USA.

The Journal of Parasitology
|March 3, 2001
PubMed
Summary

This review covers African trypanosomiases in humans and cattle, detailing the molecular mechanisms of immune control against these parasites in various hosts. It highlights current challenges and research directions in combating these diseases.

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Area of Science:

  • Veterinary Medicine
  • Parasitology
  • Immunology

Background:

  • Human and bovine trypanosomiases, caused by African trypanosomes, pose significant health and economic burdens.
  • Understanding the host-parasite interactions is crucial for developing effective control strategies.

Purpose of the Study:

  • To review the current status of human and bovine trypanosomiases.
  • To elucidate the molecular basis of innate and acquired immunity against African trypanosomes.
  • To discuss control mechanisms in humans, cattle, and Cape buffalo.

Main Methods:

  • Literature review of existing research on trypanosomiasis.
  • Analysis of molecular and immunological studies on host defense mechanisms.
  • Comparative assessment of parasite control in different host species.

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Main Results:

  • African trypanosomes evade host immune responses through various molecular strategies.
  • Both innate and acquired immunity play critical roles in controlling parasite infections.
  • Differences in host susceptibility and resistance are influenced by genetic and immunological factors.

Conclusions:

  • Further research into the molecular basis of immunity is essential for novel therapeutic and prophylactic interventions.
  • Integrated control strategies targeting parasite evasion mechanisms are needed.
  • Continued surveillance and research are vital for managing trypanosomiases in endemic regions.