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Oxidative and glycogenolytic cCapacities within the developing chick heart.

R Romano1, A C Rochat, P Kucera

  • 1Institute of Physiology, Faculty of Medicine, University of Lausanne, CH-1005 Lausanne, Switzerland.

Pediatric Research
|March 3, 2001
PubMed
Summary

Embryonic chick hearts rely on both aerobic and anaerobic pathways for energy. Ventricular wall stretch significantly impacts oxygen demand, while the atrium best utilizes its energy capacities.

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Area of Science:

  • Cardiovascular physiology
  • Developmental biology
  • Cellular metabolism

Background:

  • Cardiac function relies on aerobic and anaerobic energy pathways.
  • The specific roles of mitochondrial oxidation and glycogenolysis in embryonic heart chambers are not fully understood.
  • Factors influencing oxygen demand in embryonic cardiac chambers require investigation.

Purpose of the Study:

  • To investigate the relative contributions of mitochondrial oxidation and glycogenolysis in embryonic chick heart chambers.
  • To determine the factors affecting oxygen demand in the atrium, ventricle, and conotruncus.
  • To explore the metabolic adaptations during embryonic heart development.

Main Methods:

  • Isolated, spontaneously beating chick embryos hearts (stages 11, 20, 24HH) were studied in vitro.

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  • Oxygen (O(2)) uptake and glycogenolytic rates were measured in different cardiac chambers.
  • Metabolic conditions were controlled, including the absence or presence of glucose and mechanical loading.

    • Main Results:

    • Oxidative capacity was highest in atria at stage 20HH and did not depend on exogenous glucose.
    • Highest reserves of oxidative capacity were observed in the conotruncus and at the earliest stage.
    • Ventricular mechanical loading increased oxidative capacity by 62%, highlighting stretch as an oxygen demand determinant.

    Conclusions:

    • The atrium demonstrates the most effective utilization of both oxidative and glycogenolytic capacities.
    • Ventricular wall stretch is an early and significant factor influencing oxygen uptake in the embryonic heart.
    • Evidence suggests an active glycerol-phosphate shuttle in embryonic cardiomyocytes.