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In vivo tracking of tumor-specific T cells
C Yee1, S R Riddell, P D Greenberg
1Fred Hutchinson Cancer Research Center and University of Washington Medical Center, 1100 Fairview Avenue North, D3-100, Seattle, WA 98109, USA. cyee@fhcrc.org
Current Opinion in Immunology
|March 3, 2001
Abstract:
Novel immunologic assays now enable visualization of the antigen-specific response to an extent not previously possible. Assessment of not only the numeric frequency but also the functional properties of individual tumor-specific T cells in the endogenous and manipulated immune response has provided insights that will facilitate the development of immunotherapeutic strategies.