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Molecular determinants of TCR expression and selection

L J Berg1, J Kang

  • 1Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA.

Current Opinion in Immunology
|March 3, 2001
PubMed
Summary

T cell development relies on T cell receptor (TCR) gene signaling for thymocyte survival and maturation. Recent research illuminates molecular mechanisms governing T cell lineage commitment, including alpha-beta versus gamma-delta fate and CD4 or CD8 expression.

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