Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The angular gyrus in developmental dyslexia: task-specific differences in functional connectivity within posterior

K R Pugh1, W E Mencl, B A Shaywitz

  • 1Department of Pediatrics, Yale University School of Medicine, P.O. Box 3333, New Haven, CT 06510-8064, USA.

Psychological Science
|March 7, 2001
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The nature and interpretation of BOLD signals in white matter - A review.

Magnetic resonance imaging·2025
Same author

Exploring the diagnostic and prognostic utility of resting state functional MRI connectivity in acute/sub-acute TBI.

medRxiv : the preprint server for health sciences·2025
Same author

Tissue sodium content in patients with systemic lupus erythematosus: association with disease activity and markers of inflammation.

Lupus·2020
Same author

Food image-induced brain activation is not diminished by insulin infusion.

International journal of obesity (2005)·2016
Same author

Whole Language vs. Code Emphasis: Underlying assumptions and their implications for reading instruction.

Annals of dyslexia·2013
Same author

Face-specific processing in the human fusiform gyrus.

Journal of cognitive neuroscience·2013
Same journal

How Does the Mind Grow? Cross-Cultural Intuitive Theories of Mental Development.

Psychological science·2026
Same journal

Not All Practice Is Created Equal: Longitudinal Evidence From Over 40,000 Chess Players.

Psychological science·2026
Same journal

Eye Glint as a Novel Perceptual Cue in Human Vision.

Psychological science·2026
Same journal

Multitarget Visual Search Flexibly Switches Between Concurrent and Sequential Search Modes.

Psychological science·2026
Same journal

Motive Alignment Promotes Adolescents' Proenvironmental Behavior: A Field Experiment in Two Cultures.

Psychological science·2026
Same journal

Retributive Sentiments Track Both Deterrent and Compensatory Concerns in a Small-Scale Society and a WEIRD Sample.

Psychological science·2026
See all related articles
This summary is machine-generated.

Neuroimaging reveals that developmental dyslexia involves disrupted left-hemisphere brain connectivity during phonological assembly tasks. Right-hemisphere regions may compensate for these phonological processing deficits.

Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Cognitive Science

Background:

  • Neuroimaging studies consistently show dysfunction in posterior brain regions, particularly the left angular gyrus, in individuals with developmental dyslexia.
  • Understanding the functional connectivity within these brain networks is crucial for elucidating the neurobiological underpinnings of dyslexia.

Purpose of the Study:

  • To investigate the functional connectivity between the angular gyrus and related occipital and temporal regions during tasks with varying phonological assembly demands.
  • To determine if disruptions in functional connectivity are specific to phonological processing in developmental dyslexia.

Main Methods:

  • Examined functional connectivity (covariance) between the angular gyrus and associated posterior brain areas.
  • Utilized a series of print tasks that systematically manipulated the cognitive load on phonological assembly.

Related Experiment Videos

  • Compared connectivity patterns in dyslexic readers and nonimpaired readers.

    • Main Results:

    • A disruption in functional connectivity within the left hemisphere language network was observed in dyslexic readers, specifically during tasks requiring explicit phonological assembly.
    • In contrast, functional connectivity was robust for both dyslexic and nonimpaired readers on print tasks that did not necessitate phonological assembly.
    • Evidence suggests that right-hemisphere posterior regions may play a compensatory role in phonological processing for dyslexic individuals.

    Conclusions:

    • The neurobiological anomalies associated with developmental dyslexia appear primarily confined to the phonological processing domain.
    • Functional connectivity disruptions are task-specific, highlighting the critical role of phonological assembly in the observed deficits.
    • The findings support a model where right-hemisphere engagement can compensate for left-hemisphere phonological processing weaknesses in dyslexia.