Related Experiment Videos
Serum vitamin E in chronic myeloid leukaemia
V Singh1, S Kharb, P S Ghalaut
1Pt. BD Sharma PGIMS, Rohtak 124001, Haryana.
The Journal of the Association of Physicians of India
|March 7, 2001
Summary
Serum vitamin E levels are significantly lower in chronic myeloid leukemia (CML) patients compared to healthy individuals. Treatment for CML led to increased vitamin E levels, suggesting a reduction in oxidative stress.
Area of Science:
- Biochemistry
- Oncology
- Nutritional Science
Background:
- Free radicals are implicated in tumor promotion and malignant transformation.
- Alpha-tocopherol (vitamin E) acts as a primary antioxidant, protecting against lipid peroxidation.
- Oxidative stress plays a role in the pathogenesis of various cancers, including leukemia.
Purpose of the Study:
- To investigate serum vitamin E levels in patients diagnosed with chronic myeloid leukemia (CML).
- To assess the impact of CML treatment on serum vitamin E concentrations.
Main Methods:
- Serum vitamin E levels were quantified in 25 CML patients.
- Measurements were taken before and after therapeutic intervention.
- A control group of 25 age- and sex-matched healthy individuals was included for comparison.
Main Results:
- CML patients exhibited significantly lower mean serum vitamin E levels compared to the control group prior to treatment.
- Following treatment, serum vitamin E levels in CML patients showed a significant increase.
- Despite the increase, post-treatment vitamin E levels remained below those observed in healthy controls.
Conclusions:
- Patients with CML demonstrate reduced serum vitamin E levels.
- Therapeutic intervention for CML results in a significant elevation of serum vitamin E.
- The observed changes in vitamin E levels may reflect a decrease in oxidative stress associated with reduced tumor burden.