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Published on: May 9, 2018
Tibia metastasis without prostate specific antigen (PSA) increase following radical vesiculo-prostatectomy
Objectives:
PSA is regarded as the best method in the follow-up of prostate carcinoma. After radical vesiculo-prostatectomy the prostate carcinoma seldom recurs at zero or nearly zero PSA levels.
Methods:
The authors have used PSA since 1989 and they have found only one case where metastasis in the tibia came without an increase in PSA levels.
Results:
Tibia metastasis showed lower tissue activity of PSA than did the primary tumor in the prostate. The authors think this explains the zero PSA level when the metastasis developed.
Conclusions:
The authors think based on their case that PSA free progression prostate cacncers may cases where the metastases do not produce PSA.
