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Synthesis and biological evaluation of DNA targeting flexible side-chain substituted beta-carboline derivatives
1National Research Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, People's Republic of China.
Bioorganic & Medicinal Chemistry Letters
|March 7, 2001
Abstract:
A series of 3-substituted-beta-carboline derivatives was synthesized from L-tryptophan. The intercalating binding mode of these compounds with DNA, the effects of the flexible alkylamine side chain on the intercalating ability and their antitumor activity were studied, which agreed well with the molecular modeling results.