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Modified synthesis and antiangiogenic activity of linomide
Bioorganic & Medicinal Chemistry Letters
|March 7, 2001
Abstract:
A modified procedure for the synthesis of Linomide is described. The synthesized drug was characterized and assessed for its in vivo antiangiogenic activity. In a murine angiogenesis assay Linomide treatment inhibited new blood vessel formation as documented by reduced microvessel area and blood volume.