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First tricyclic oximino derivatives as 5-HT3 ligands
I Baglin1, C Daveu, J C Lancelot
1Centre d'Etudes et de Recherche sur le Médicament de Normandie, Université de Caen, France.
Bioorganic & Medicinal Chemistry Letters
|March 7, 2001
Abstract:
The design and synthesis of a new type of 5-HT3 ligand with subnanomolar affinity are described. The O-dialkylaminoethyloximinothienopyrrolizine structure was deduced from molecular modeling studies by replacement of an amidine moiety by an oximino one.