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Identification and characterization of a potential ischemia-selective N-methyl-D-aspartate (NMDA) receptor
S Padmanabhan1, M E Perlman, L Zhang
1Cambridge NeuroScience, Inc., Norwood, MA 02602, USA. padman@cambneuro.com
Bioorganic & Medicinal Chemistry Letters
|March 7, 2001
Abstract:
The identification and characterization of a potentially ischemia-selective and orally-active sulfoxide based NMDA ion-channel blocker showing good neuroprotective activity, (R)-(+)-N-(2-chloro-5-methylthiophenyl)-N'-(3-methylsulfinylphenyl)-N'-methylguanidine (CNS 5788), is described.