Related Experiment Videos
Semi-synthesis of 2-deoxo- and 3-epi-paraherquamide A
B H Lee1, M F Clothier, S S Johnson
1Animal Health Discovery Research, Pharmacia Corp., Kalamazoo, MI 49001, USA. bhlee@am.pnu.com
Bioorganic & Medicinal Chemistry Letters
|March 7, 2001
Abstract:
2-Deoxo- and 3-epi-paraherquamide A were synthesized from paraherquamide A. 2-Deoxoparaherquamide A has good activity against HC and TC in our jird model comparable to the parent compound, while 3-epi-paraherquamide A showed no activity.
Related Concept Videos
Articles linked to this work by shared authors, journal, and citation graph.
Sulfur Species in Zinc-Rich Condylar Zones of a Rat Temporomandibular Joint.
Journal of dental research·2025
Chewing-Activated TRPV4/PIEZO1-HIF-1α-Zn Axes in a Rat Periodontal Complex.
Journal of dental research·2025
Context-aware deep network for coronary artery stenosis classification in coronary CT angiography.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2023
Metagenome-Assembled Genome of a Putative Chemoheterotroph from Volcanic Terrain in Hawaii.
Microbiology resource announcements·2022
Basaltic Lava Tube Hosts a Putative Novel Genus in the Family Solirubrobacteraceae.
Microbiology resource announcements·2022
Discovery of potent, selective, and orally bioavailable monocyclic pyridine-based PKMYT1 inhibitors that synergize with CHK1 inhibition in replication-stressed cancer cells.
Bioorganic & medicinal chemistry letters·2026
Quinolin(on)es and pyridin(on)es as promising scaffolds against mycobacterial infections.
Bioorganic & medicinal chemistry letters·2026
Amyloid-β aggregation inhibitory activity and neuroprotective effects of metabolites of Trichoderma pluripenicillatum.
Bioorganic & medicinal chemistry letters·2026
Electrophilic aromatic halogenation of perylenequinones: a strategy to improve photodynamic properties.
Bioorganic & medicinal chemistry letters·2026
Discovery of novel dual STAT3/TrxR1 inhibitors via pharmacophore fusion as potent lead compounds for colorectal cancer.
Bioorganic & medicinal chemistry letters·2026
Chelidonium majus L. alkaloid extract encapsulated in human serum albumin nanoparticles induces mitochondria-mediated apoptosis in HeLa cell line.
Cellular and molecular biology (Noisy-le-Grand, France)·2026
Reduced severe infection risk with avacopan in ANCA-associated vasculitis: a multicentre REVEAL cohort with time-varying exposure modelling.
Rheumatology (Oxford, England)·2026
[Expression of Concern] Ginsenoside Rg1 protects against H2O2‑induced neuronal damage due to inhibition of the NLRP1 inflammasome signalling pathway in hippocampal neurons in vitro.
International journal of molecular medicine·2026
Development of an MSPE-UHPLC-MS/MS method for bisphenols and alkylphenols in personal care products: a pilot study and preliminary safety assessment in China.
Analytical methods : advancing methods and applications·2026