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Porcine factor V: cDNA cloning, gene mapping, three-dimensional protein modeling of membrane binding sites and

D R Grimm1, M B Colter, M Braunschweig

  • 1Shriners Hospital for Children, Center for Research in Skeletal Development and Pediatric Orthopedics, Special Shared Facility, Tampa, Florida 33612, USA. dgrimm@shctampa.usf.edu

Cellular and Molecular Life Sciences : CMLS
|March 7, 2001
PubMed

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Conserved Binding Sites01:49

Conserved Binding Sites

Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally analyses the...