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Updated: Jul 21, 2026
07:29
Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
Postprandial lipoproteins and atherosclerosis
1Research Institute, Ames Building, Palo Alto Medical Foundation 795 El Camino Real, Palo Alto, CA 94301, USA.
Frontiers in Bioscience : a Journal and Virtual Library
|March 7, 2001
Summary
Dietary lipids form chylomicrons, which are processed into remnants cleared by the liver. Impaired remnant removal is linked to coronary heart disease and lipid disorders.
Area of Science:
- Lipid metabolism
- Cardiovascular science
- Molecular biology
Background:
- Dietary lipids are transported via chylomicrons post-meal.
- Chylomicrons deliver fatty acids to tissues, forming remnants.
- Remnants are cleared by the liver through specific receptors.
Purpose of the Study:
- To review the metabolic pathway of postprandial lipoproteins.
- To detail the liver's role and receptors in remnant clearance.
- To discuss the atherogenic potential of chylomicron remnants.
Main Methods:
- Review of the exogenous metabolic pathway.
- Analysis of hepatic clearance mechanisms.
- Examination of receptor-mediated uptake (LDLR, LRP).
Main Results:
- Chylomicron remnants are formed after triglyceride hydrolysis.
- Hepatic uptake involves LDLR, LRP, and potentially HSPG/hepatic lipase.
- Slow remnant clearance correlates with coronary heart disease and dyslipidemias.
Conclusions:
- Efficient chylomicron remnant clearance is crucial for cardiovascular health.
- Dysfunctional remnant metabolism contributes to atherosclerosis.
- Understanding this pathway informs therapeutic strategies for lipid disorders.
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