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Relation of two different subtypes of croup before age three to wheezing, atopy, and pulmonary function during

J A Castro-Rodríguez1, C J Holberg, W J Morgan

  • 1Respiratory Sciences Center, University of Arizona, College of Medicine, Tucson, Arizona, USA.

Pediatrics
|March 7, 2001
PubMed

Insights

Croup in early life may increase the risk of persistent wheeze, especially when accompanied by wheezing. Lung function abnormalities are linked to croup, with outcomes depending on initial airway involvement.

Area of Science:

  • Pediatric Pulmonology
  • Respiratory Medicine
  • Epidemiology

Background:

  • Croup in early life has been anecdotally linked to later respiratory issues.
  • Previous studies suggest a potential association between croup and conditions like asthma and reduced lung function.

Purpose of the Study:

  • To investigate the long-term respiratory outcomes of physician-diagnosed croup in early childhood.
  • To determine if croup increases the risk of subsequent asthma, atopy, or diminished pulmonary function.

Main Methods:

  • A longitudinal study of 884 children from birth, assessing lower respiratory illnesses (LRIs) in the first 3 years.
  • Pulmonary function tests, atopy markers, and wheezing episodes were tracked up to age 13.

Main Results:

  • Croup with wheeze (10%) and other LRIs (36%) were associated with a higher risk of persistent wheeze later in life.
  • Children with croup and wheeze showed significantly lower intrapulmonary airway function indices.
  • No association was found between croup and atopy markers in school-aged children.

Conclusions:

  • Croup presents with distinct manifestations (with or without wheezing).
  • The risk of recurrent lower airway obstruction post-croup depends on initial airway involvement and lung function.
  • Early life croup can be a predictor of future respiratory issues, particularly when wheezing is present.
Abstract

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