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Tretinoin peeling
L C Cucé1, M C Bertino, L Scattone
1Department of Dermatology, "Universidade de Santo Amaro" (UNISA) Medical School, and "Universidade de São Paulo"(USP), São Paulo, Brazil.
Background:
Topical tretinoin has been used for a long time to improve photoaged skin, but this therapy takes quite a few months to show some clinical changes. Because of that, we think tretinoin peeling would be an excellent choice for improvement of photoaged skin.
Objective:
[corrected] Our objective was to show the clinical and histologic modifications of the skin after five sessions of tretinoin peeling.
Methods:
The authors studied the clinical and histologic modification that occurred in 15 female patients after conducting tretinoin peeling procedures twice a week in concentrations of 1-5%. Conventional sectioning of punch biopsy specimens was conducted before and after the treatment.
Results:
Clinical improvement was observed in the skin texture and appearance. Through histologic examinations, a decrease in the corneous layer and an increase in the epidermal thickness were noticed, inducing an improvement of its stratification, as well as the formation of cristae cutis.
Conclusion:
It was concluded that the peeling conducted with serial tretinoin showed good clinical and histologic results, especially for the treatment of photoaged skins I and II, melasma, ephelis, and acne degree I, as well as being practical, quick, and easily accomplished with no side effects.