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Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming

J Wolfers1, A Lozier, G Raposo

  • 1Immunology Unit, Department of Clinical Biology, Institut Gustave Roussy, Villejuif, France.

Nature Medicine
|March 7, 2001
PubMed

The initiation of T-cell-mediated antitumor immune responses requires the uptake and processing of tumor antigens by dendritic cells and their presentation on MHC-I molecules. Here we show in a human in vitro model system that exosomes, a population of small membrane vesicles secreted by living tumor cells, contain and transfer tumor antigens to dendritic cells. After mouse tumor exosome uptake, dendritic cells induce potent CD8+ T-cell-dependent antitumor effects on syngeneic and allogeneic established mouse tumors. Therefore, exosomes represent a novel source of tumor-rejection antigens for T-cell cross priming, relevant for immunointerventions.

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