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Updated: Aug 9, 2026

Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye
Published on: June 20, 2015
Increased corneal thickness in patients with ocular hypertension
D C Herman1, D O Hodge, W M Bourne
1Department of Ophthalmology, Mayo Clinic and Foundation, 200 First St SW, Rochester, MN 55905, USA. herman.david@mayo.edu
Background:
Central corneal thickness greater than 0.520 mm causes true intraocular pressure to be overestimated when the technique of applanation tonometry is used to measure intraocular pressure.
Objective:
To compare the corneal thickness measurements of patients enrolled in a study of ocular hypertension with those of age-matched control subjects with normal intraocular pressure.
Methods:
Central corneal pachymetry using an optical pachymeter was performed on each study subject (n = 55) at baseline and in an independent sample of control subjects. A 2 sample, 2-tailed T test was used to compare the 2 populations.
Results:
The patients with ocular hypertension had significantly higher mean corneal thickness measurements (mean +/- SD, 0.594 +/- 0.037 mm) than the control group (0.563 +/- 0.027 mm) (P<.001).
Conclusion:
Corneal thickness may be a confounding factor in the measurement of intraocular pressure, and this may modify the risk for progression to glaucoma in patients with ocular hypertension.
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