Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Using evidence from different sources: an example using paracetamol 1000 mg plus codeine 60 mg.

L A Smith1, R A Moore, H J McQuay

  • 1Pain Research & Nuffield Department of Anaesthetics, University of Oxford, Oxford, UK. lesley.smith@pru.ox.ac.uk

BMC Medical Research Methodology
|March 7, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Using Advanced Cell Culture Techniques to Differentiate Pluripotent Stem Cells and Recreate Tissue Structures Representative of Teratoma Xenografts.

Frontiers in cell and developmental biology·2021
Same author

Applications of novel bioreactor technology to enhance the viability and function of cultured cells and tissues.

Interface focus·2020
Same author

Ubiquitous parasites drive a 33% increase in methane yield from livestock.

International journal for parasitology·2018
Same author

To fill or not to fill: a qualitative cross-country study on dentists' decisions in managing non-cavitated proximal caries lesions.

Implementation science : IS·2018
Same author

Correction to: Dexketoprofen/tramadol 25 mg/75 mg: randomised double-blind trial in moderate-to-severe acute pain after abdominal hysterectomy.

BMC anesthesiology·2017
Same author

A mathematical model of antibody-dependent cellular cytotoxicity (ADCC).

Journal of theoretical biology·2017

Combining paracetamol 1000 mg and codeine 60 mg effectively manages acute postoperative pain. High-quality trials beyond placebo-controlled studies support its efficacy for pain relief.

Area of Science:

  • Pharmacology and Pain Management
  • Clinical Trial Methodology

Background:

  • Traditional meta-analyses often exclude high-quality data beyond randomized, double-blind, placebo-controlled trials.
  • This approach may limit the comprehensive understanding of treatment efficacy.
  • Exploring diverse trial designs can enrich meta-analytic evidence.

Purpose of the Study:

  • To investigate the efficacy of combining paracetamol 1000 mg and codeine 60 mg for acute postoperative pain.
  • To explore the utility of including data from various high-quality trial designs in meta-analysis.

Main Methods:

  • Analysis of randomized, double-blind, placebo-controlled trials for paracetamol 1000 mg and codeine 60 mg.
  • Inclusion of data from controlled trials lacking placebo and dose-response studies.

Related Experiment Videos

  • Exclusion of trials with design inconsistencies to maintain data integrity.

    • Main Results:

    • The combination demonstrated a number needed to treat (NNT) of 2.2 for 50% pain relief in placebo-controlled trials.
    • Computer simulations confirmed the reliability of the NNT estimate.
    • Non-placebo controlled trials showed 73% of patients achieving 50% pain relief, compared to 57% in placebo-controlled trials.

    Conclusions:

    • High-quality trials with varied designs can supplement meta-analysis findings.
    • This approach enhances the evidence base without compromising scientific rigor.
    • The combination of paracetamol 1000 mg and codeine 60 mg is effective for acute postoperative pain.