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Related Experiment Videos

Negative energy balance does not decrease expression of leukocyte adhesion or antigen-presenting molecules in cattle.

K H Perkins1, M J VandeHaar, R J Tempelman

  • 1Department of Animal Science, Michigan State University, East Lansing 48824, USA.

Journal of Dairy Science
|March 10, 2001
PubMed
Summary
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Nutritional negative energy balance in Holstein steers increased serum nonesterified fatty acids (NEFA). While CD62L expression on neutrophils rose, overall immune cell adhesion molecule and MHC expression remained largely unaffected, suggesting resilience.

Area of Science:

  • Animal Science
  • Immunology
  • Nutritional Physiology

Background:

  • Energy balance significantly impacts animal health and immune function.
  • Understanding how nutritional deficits affect immune cell markers is crucial for livestock management.

Purpose of the Study:

  • To investigate the effects of negative energy balance on immune cell adhesion molecules and MHC expression in yearling Holstein steers.
  • To determine if nutritional stress impairs leukocyte function.

Main Methods:

  • Holstein steers were subjected to positive or negative energy balance diets.
  • Serum nonesterified fatty acids (NEFA) were measured.
  • Leukocyte expression of L-selectin (CD62L), Mac-1 (CD11b/CD18), and MHC class I/II molecules was analyzed via flow cytometry.

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Main Results:

  • Negative energy balance significantly increased serum NEFA concentrations.
  • CD62L expression on neutrophils increased by 14% under negative energy balance (P = 0.03).
  • No significant changes were observed in CD62L on other leukocytes or in CD11b/CD18 expression. MHC class I was unaffected, while MHC class II showed a slight increase (P = 0.03).

Conclusions:

  • Nutritionally induced negative energy balance in steers had minimal impact on the expression of key adhesion molecules (CD62L, CD11b, CD18) and MHC molecules on resting leukocytes.
  • The bovine immune system appears relatively robust against short-term nutritional energy deficits concerning these specific markers.