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Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs)
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Neurodevelopmental effects: making the case for biologic plausibility.

C T De Rosa1, H E Hicks, W Cibulas

  • 1U.S. Department of Health and Human Services, Agency for Toxic Substances and Disease Registry, Atlanta, Georgia 30333, USA. cydo@cdc.gov

Neurotoxicology
|March 10, 2001
PubMed
Summary

Establishing a definite cause-effect link between environmental toxins and adverse health outcomes is challenging. A weight of evidence approach, focusing on biologic plausibility, can inform public health policy for neurodevelopmental effects.

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Area of Science:

  • Environmental Health
  • Toxicology
  • Neuroscience

Background:

  • Establishing causality between environmental exposures and adverse health effects is difficult.
  • The tobacco debate highlights challenges in scientific certainty for policy.
  • A weight of evidence approach using biologic plausibility is proposed as a surrogate for causality.

Purpose of the Study:

  • To examine findings supporting the biologic plausibility of neurodevelopmental effects from environmental exposures.
  • To explore the utility of biologic plausibility in translating scientific evidence into public health policy.
  • To review research from the Great Lakes Basin and other areas.

Main Methods:

  • Review of scientific findings from wildlife biology, toxicology, and epidemiology.
  • Examination of research on neurodevelopmental effects.
  • Focus on persistent toxic substances and their environmental exposures.

Main Results:

  • Biologic plausibility for neurodevelopmental effects is supported by evidence from multiple scientific disciplines.
  • Research in the Great Lakes Basin provides a significant case study.
  • Environmental exposures to persistent toxic substances are linked to potential neurodevelopmental impacts.

Conclusions:

  • Biologic plausibility serves as a crucial link between scientific findings and policy decisions regarding environmental health.
  • A weight of evidence approach strengthens the foundation for public health action on neurodevelopmental effects.
  • Continued research, particularly in areas like the Great Lakes, is vital for understanding environmental risks.