Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neurodevelopmental effects: making the case for biologic plausibility.

C T De Rosa1, H E Hicks, W Cibulas

  • 1U.S. Department of Health and Human Services, Agency for Toxic Substances and Disease Registry, Atlanta, Georgia 30333, USA. cydo@cdc.gov

Neurotoxicology
|March 10, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Coupling between waveguides and microresonators: the local approach.

Optics express·2020
Same author

Pruritus secondary to primary biliary cholangitis: a review of the pathophysiology and management with phototherapy.

The British journal of dermatology·2019
Same author

Editorial: scoring systems in primary biliary cholangitis - time to make a move.

Alimentary pharmacology & therapeutics·2017
Same author

Nanofiber-segment ring resonator.

Optics letters·2016
Same author

Molecular mechanisms for anthelmintic resistance in strongyle nematode parasites of veterinary importance.

Journal of veterinary pharmacology and therapeutics·2016
Same author

Revised Recommendations of the Consortium of MS Centers Task Force for a Standardized MRI Protocol and Clinical Guidelines for the Diagnosis and Follow-Up of Multiple Sclerosis.

AJNR. American journal of neuroradiology·2015
Same journal

Paternal Exposure to Chlorpyrifos Disrupts Protein Regulation and Abolishes PKCβ Signaling in Learning‑Related Neural Circuits.

Neurotoxicology·2026
Same journal

Zebrafish Behavioral Assessment as a First-Tier Whole-Organism NAM for Developmental Neurotoxicity: A Multi-Laboratory Evaluation.

Neurotoxicology·2026
Same journal

Adolescent prefrontal and amygdala molecular signatures of perinatal morphine versus buprenorphine exposure in mice.

Neurotoxicology·2026
Same journal

A Multiparametric 3D Cortical Neurosphere NAM for Developmental Neurotoxicity: Chlorpyrifos and a Biomonitoring-Anchored PFAS Mixture.

Neurotoxicology·2026
Same journal

Mechanisms of Nicotine Toxicity and Addiction-like Behavior in Drosophila melanogaster: The Role of α7 & β2 Nicotinic Acetylcholine Receptor Subunits in Sensory Valence and Cellular Stress.

Neurotoxicology·2026
Same journal

PM<sub>2.5</sub> exposure exacerbates cerebral infarction via HPG axis downregulation and pituitary lipid metabolism dysregulation in mice.

Neurotoxicology·2026
See all related articles

Establishing a definite cause-effect link between environmental toxins and adverse health outcomes is challenging. A weight of evidence approach, focusing on biologic plausibility, can inform public health policy for neurodevelopmental effects.

Area of Science:

  • Environmental Health
  • Toxicology
  • Neuroscience

Background:

  • Establishing causality between environmental exposures and adverse health effects is difficult.
  • The tobacco debate highlights challenges in scientific certainty for policy.
  • A weight of evidence approach using biologic plausibility is proposed as a surrogate for causality.

Purpose of the Study:

  • To examine findings supporting the biologic plausibility of neurodevelopmental effects from environmental exposures.
  • To explore the utility of biologic plausibility in translating scientific evidence into public health policy.
  • To review research from the Great Lakes Basin and other areas.

Main Methods:

  • Review of scientific findings from wildlife biology, toxicology, and epidemiology.

Related Experiment Videos

  • Examination of research on neurodevelopmental effects.
  • Focus on persistent toxic substances and their environmental exposures.

    • Main Results:

    • Biologic plausibility for neurodevelopmental effects is supported by evidence from multiple scientific disciplines.
    • Research in the Great Lakes Basin provides a significant case study.
    • Environmental exposures to persistent toxic substances are linked to potential neurodevelopmental impacts.

    Conclusions:

    • Biologic plausibility serves as a crucial link between scientific findings and policy decisions regarding environmental health.
    • A weight of evidence approach strengthens the foundation for public health action on neurodevelopmental effects.
    • Continued research, particularly in areas like the Great Lakes, is vital for understanding environmental risks.