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Analysis of HLA antigens in Croatian patients with psoriasis
M Kastelan1, F Gruber, E Cecuk
1Department of Dermatology, University Hospital Rijeka, Kresimirova 42, HR-Rijeka 51000, Croatia.
Insights
Certain human leukocyte antigen (HLA) types are linked to psoriasis risk. The HLA-Cw*0602 allele shows the strongest association, particularly in early-onset psoriasis patients with a family history.
Area of Science:
- Immunogenetics
- Dermatology
- Human Leukocyte Antigen (HLA) complex
Background:
- Psoriasis, a common autoimmune disease, exhibits associations with specific human leukocyte antigen (HLA) antigens.
- Understanding these genetic associations is crucial for elucidating disease pathogenesis and identifying at-risk populations.
Purpose of the Study:
- To investigate the distribution of HLA antigens in Croatian psoriasis patients.
- To identify specific HLA associations with different psoriasis subtypes based on onset age and family history.
Main Methods:
- Serological analysis of HLA antigens in 108 Croatian psoriasis patients and controls.
- Polymerase chain reaction (PCR) for HLA-C allele typing.
- Stratification of patients into Type I (early onset, positive family history) and Type II (late onset, no family history) groups.
Main Results:
- Significant increases in HLA-A2, -B17, -B37, -B13, HLA-Cw*0602, and DR7 antigens were observed in psoriatic patients.
- Type I psoriasis showed strong associations with HLA-Cw*0602 (p < 0.00001; RR = 14.45) and DR7 (p < 0.00001; RR = 15.09).
- Type II psoriasis demonstrated a significant association with HLA-Cw*03 (p = 0.008; RR = 0.17).
Conclusions:
- HLA-B13, -B17, -Cw*0602, and -DR7 antigens are associated with increased psoriasis risk in the Croatian population.
- The HLA-Cw*0602 allele exhibits the strongest association, particularly for Type I psoriasis.
- These findings highlight the importance of specific HLA alleles in psoriasis susceptibility and classification.
Abstract:
In common with most autoimmune diseases, psoriasis is associated with some HLA antigens. We studied the distribution of HLA antigens in Croatian patients with psoriasis: 108 patients were divided into groups according to family history and age of disease onset. HLA antigens were analyzed serologically and HLA-C alleles were analyzed using polymerase chain reaction. We found significant increases in HLA-A2, -B17, -B37 and -B13 antigens and highly significant increases in HLA-Cw*0602 and DR7 antigens in psoriatic patients compared with controls. Patients with type I psoriasis (early onset, positive family history) showed highly significant associations with Cw*0602 [p < 0.00001; relative risk (RR) = 14.45] and DR7 (p < 0.00001; RR = 15.09) antigens. Patients with type II psoriasis (late onset, no family history) had a significant association with Cw*03 antigen (p = 0.008; RR = 0.17). In conclusion, HLA-B13, -B17, Cw*0602 and -DR7 antigens are associated with a significant risk of psoriasis in the Croatian population and the Cw*0602 allele has the strongest association, especially for type I psoriasis.