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Updated: Aug 3, 2026

Depletion and Reconstitution of Macrophages in Mice
Published on: August 1, 2012
[Robert R. Macintosh and Spain: a productive relationship]
M C Unzueta Merino1, C Hervás Puyal, J Villar Landeira
1Servicio de Anestesiología, Reanimación y Terapéutica del Dolor, Hospital de la Santa Creu i Sant Pau, San Antonio M. Claret, 167, 08025 Barcelona.
Abstract:
Through his visit to Spain in 1946, Robert R. Macintosh exercised considerable influence on the introduction and development of modern anesthesia in this country. This paper reviews the technical advances Mackintosh introduced and considers how his visit was one of the most important factors in unleashing the development of the profession here. Also reviewed are the other visits Mackintosh made in the course of his career. Those trips were less important, with the exception of a 1937 visit that inspired the design of the Oxford vaporizer, a technical concept based on simplicity, safety and the anesthesiologist's experience.
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