Related Experiment Video
Updated: Oct 9, 2026

A Murine Model of Group B Streptococcus Vaginal Colonization
Published on: November 16, 2016
Group A streptococcus clones causing repeated epidemics and endemic disease in intravenous drug users
1Department of Internal Medicine, University Hospital, University of Berne, Switzerland.
Abstract:
Clones of Group A streptococcus (GAS) may spread epidemically and may be associated with enhanced virulence. Sociodemographic and clinical characteristics, together with bacterial isolates, of 79 patients with GAS infection in the Berne region between January 1993 and February 1997 were analysed retrospectively. Using pulsed-field gel electrophoresis, most strains (71%) were found to belong to one of 12 clones. Clonal strains caused significantly more frequent skin abscesses and more severe invasive disease than non-clonal strains. The largest clone (M serotype 1) occurred endemically in non-IVDU patients and caused severe disease in most. Three clones occurred almost exclusively among IVDUs: an M serotype 11 was associated with severe, endemic disease; the other 2 clones, both of M serotype 25, caused epidemics of needle abscesses. Epidemic and endemic spread of GAS clones among IVDUs may be more frequent than previously assumed.
More Related Videos
09:25Implementation of a Permeable Membrane Insert-based Infection System to Study the Effects of Secreted Bacterial Toxins on Mammalian Host Cells
Published on: August 19, 2016
08:03Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
Published on: December 7, 2021
Related Concept Videos
Infectious Diseases and Their Occurrence
Streptococcal Pharyngitis
Endocarditis I: Introduction
Drug Accumulation During Multiple Dosing: Intermittent IV Infusions
Staphylococcal Skin Infections
Drug Accumulation During Multiple Dosing: Repetitive IV Injections