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Updated: Aug 19, 2026

Rotating the Intraocular Lens to Prevent Posterior Capsular Opacification in Cataract Surgeries
Published on: July 7, 2023
[Presence of alpha 5 beta 1 integrin and fibronectin in the anterior subcapsular cataract]
M Yoshino1, D Kurosaka, M Obazawa
1Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinnjuku-ku, Tokyo 160-8582, Japan.
Purpose:
We investigated whether alpha 5 beta 1 integrin and fibronectin were present in myofibroblast-like lens epithelial cells in anterior subcapsular cataract (ASC).
Methods:
Nine anterior capsule specimens were obtained from the patients during cataract surgery and frozen for cryostat sections. Six specimens were anterior capsule obtained from cataract with ASC. As a control, three specimens were obtained from cataract without ASC. Alpha-smooth muscle actin (alpha-SMA), alpha 5 beta 1 integrin, and fibronectin were detected by immunohistochemical observation.
Results:
In all 6 specimens from patients with ASC, the lens epithelial cells around fibrosis tissue included myofibroblast-like lens epithelial cells which were positive for alpha-SMA. alpha 5 beta 1 integrin was detected in these lens epithelial cells. Fibronectin was also detected around these myofibroblast-like lens epithelial cells. Three control specimens showed no immunoreactivity against alpha-SMA, alpha 5 beta 1 integrin, or fibronectin.
Conclusions:
Alpha 5 beta 1 integrin and fibronectin may play an important role in myodifferentiation of lens epithelial cells.
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