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Related Experiment Videos

Risperidone versus pimozide in Tourette's disorder: a comparative double-blind parallel-group study.

R Bruggeman1, C van der Linden, J K Buitelaar

  • 1Department of Psychiatry, Sint Lucas-Andreas Ziekenhuis, Amsterdam, The Netherlands.

The Journal of Clinical Psychiatry
|March 10, 2001
PubMed
Summary
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Risperidone and pimozide effectively treated Tourette's disorder, with risperidone showing a better side effect profile. This suggests risperidone could be a preferred first-line treatment for Tourette's disorder.

Area of Science:

  • Neurology
  • Psychiatry
  • Pharmacology

Background:

  • Tourette's disorder treatment is often limited by classical neuroleptic side effects.
  • Risperidone, an antipsychotic with fewer extrapyramidal side effects, was investigated for Tourette's disorder.
  • This study compared risperidone's safety and efficacy against pimozide in Tourette's disorder patients.

Purpose of the Study:

  • To evaluate the therapeutic potential of risperidone in Tourette's disorder.
  • To compare the safety and efficacy of risperidone versus pimozide.
  • To assess treatment outcomes using standardized scales for tics, global functioning, and mood.

Main Methods:

  • A 12-week, multicenter, double-blind, parallel-group study.
  • 26 patients received risperidone (mean daily dose 3.8 mg), and 24 received pimozide (mean daily dose 2.9 mg).

Related Experiment Videos

  • Evaluations included the Tourette's Symptom Severity Scale (TSSS), Global Assessment of Functioning, and Clinical Global Impressions scales.

    • Main Results:

    • Both risperidone and pimozide significantly improved tics and overall functioning.
    • Risperidone showed a higher rate of very mild or no symptoms (54%) compared to pimozide (38%) on the TSSS global severity rating.
    • Fewer patients on risperidone reported extrapyramidal side effects (4 vs. 8).
    • Obsessive-compulsive behaviors improved significantly only in the risperidone group.

    Conclusions:

    • Both risperidone and pimozide are effective and well-tolerated treatments for Tourette's disorder.
    • Risperidone demonstrated a more favorable efficacy and tolerability profile.
    • Risperidone may be considered a potential first-line treatment for Tourette's disorder.