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[Searching for the optimal combinations of regulator anxiolytic peptides: theoretical rationale]
1Biological Faculty, Moscow State University, Vorob'evy gory, Moscow, 119899 Russia.
Izvestiia Akademii Nauk. Seriia Biologicheskaia
|March 10, 2001
Abstract:
A vector method is proposed to initially select the complexes of regulatory peptides (RPs) with certain functional characteristics. As the result of a theoretical search for the optimal combinations of anxiolytic RPs with different spectra of side effects, the following complexes are proposed for subsequent experimental investigation: NPY-ANP, NPY-SP, NPY-NT, NPY-CGRP, NPY-DSIP, NPY-MIF-1, NPY-SP-MIF-1, NPY-ANP-DSIP, and NPY-CGRP-DSIP.