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[Experimental study on an animal model of axonal form Guillain-Barre syndrome]
Objective:
To investigate an animal model of axonal form Guillain-Barre syndrome (GBS).
Methods:
A strain of Campylobacter jejuni (Cj PENO: 19) from stools of a patient with axonal form GBS was isolated. After the lypopolysaccharides (LPS) were extracted from the strain, they were inoculated into 26 rabbits, 10 micrograms per week.
Results:
Three rabbits showed paralysis, with an incidence rate of 11.54%. For the three rabbits, LPS was inoculated two, three and three times, respectively. Pathological examination showed serious axonal degeneration in the sciatic nerve. The electrophysiological features showed motor axon damage.
Conclusion:
The results suggested the presence of an axonal form GBS. LPS in Cj could play an important role in causing axonal form GBS.