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Biological features of the clone involved in primary amyloidosis (AL)
V Perfetti1, M C Vignarelli, S Casarini
1Department of Internal Medicine, IRCCS Policlinico S Matteo, University of Pavia, Italy.
Leukemia
|March 10, 2001
Abstract:
Primary light chain-associated amyloidosis (AL) is a plasma cell dyscrasia that causes morbidity via systemic tissue deposition of monoclonal light chains in the form of fibrils (amyloid). It is the most common form of systemic amyloidosis in Western countries and is rapidly fatal. Knowledge of the pathobiology of the underlying B cell clone is of primary importance for the design and optimization of therapeutic strategies.