Related Experiment Videos
Chemoprevention of lung cancer by lycopene
D J Kim1, N Takasuka, H Nishino
1Department of Pathology, National Institute of Toxicology Research, Korea FDA, Seoul. dkim0@yahoo.com
Abstract:
An investigation was conducted to assess the chemopreventive potential of lycopene (LP), a naturally occurring hydrocarbon carotenoid found in tomatoes and their products, administered during the post-initiation stage in a multiorgan carcinogenesis model. One hundred eighteen B6C3F1 mice of both sexes were subjected to combined treatment with diethylnitrosamine (DEN), N-methyl-N-nitrosourea (MNU) and 1,2-dimethylhydrazine (DMH) from day 11 after birth to week 9 (DMD treatment) (groups 1 and 2) or given their vehicles (group 3). Then group 1 received LP (25 or 50 ppm in drinking water) for 21 weeks from weeks 11 to 32. Group 2 served as a carcinogen alone control and group 3 was given only LP (25 or 50 ppm). The incidences and multiplicities of lung adenomas plus carcinomas combined in male mice in group 1 receiving LP 50 ppm were significantly decreased as compared to the DMD alone or DMD and LP 25 ppm group values (75.0 vs 18.8%, P < 0.02; 0.94+/-0.17 v.s 0.25+/-0.14, P < 0.001). While hepatocellular carcinomas were lacking in the DMD and LP groups, two cases were found in the DMD alone group (not statistically significant). The values for aberrant crypt foci (ACF) and tumors in the colon and kidney did not show any significant variation among the carcinogen-treated subgroups. The results of this study provide evidence that the tomato carotenoid, lycopene, may have potential as a chemopreventive agent against carcinogenesis in the male lung.
Insights
Lycopene, a tomato carotenoid, shows chemopreventive potential against lung cancer in male mice when administered post-carcinogenesis initiation. This study highlights lycopene
Area of Science:
- * Oncology
- * Nutritional Science
- * Carcinogenesis Research
Background:
- * Lycopene is a natural carotenoid found in tomatoes.
- * Carcinogenesis involves multiple stages, including initiation and post-initiation.
- * Chemoprevention aims to prevent or delay cancer development.
Purpose of the Study:
- * To evaluate the chemopreventive efficacy of lycopene during the post-initiation phase of carcinogenesis.
- * To assess lycopene's effect on multiorgan tumor development in a mouse model.
- * To investigate lycopene's impact on lung, liver, colon, and kidney carcinogenesis.
Main Methods:
- * A multiorgan carcinogenesis model using diethylnitrosamine, N-methyl-N-nitrosourea, and 1,2-dimethylhydrazine in B6C3F1 mice.
- * Lycopene (25 or 50 ppm) administered in drinking water during the post-initiation stage (weeks 11-32).
- * Incidence and multiplicity of tumors, including lung adenomas/carcinomas and hepatocellular carcinomas, were analyzed.
Main Results:
- * Significant reduction in lung adenoma and carcinoma incidence and multiplicity in male mice receiving 50 ppm lycopene.
- * No hepatocellular carcinomas observed in lycopene-treated groups, compared to two in the carcinogen-alone group.
- * No significant variations in aberrant crypt foci or tumors in the colon and kidney among treated subgroups.
Conclusions:
- * Lycopene demonstrates chemopreventive potential against lung carcinogenesis in male mice during the post-initiation phase.
- * Lycopene may be a promising agent for preventing chemically induced lung tumors.
- * Further research is warranted to explore lycopene's role in cancer prevention.