Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Genetics of type 1A diabetes.

M J Redondo1, P R Fain, G S Eisenbarth

  • 1Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver 80262, USA.

Recent Progress in Hormone Research
|March 10, 2001
PubMed
Summary

Genetic factors, particularly human leukocyte antigen (HLA) alleles, significantly influence Type 1A diabetes risk. Non-HLA genes and environmental factors also play a role in developing this autoimmune disease.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Metabolic, genetic and immunological features of relatives of type 1 diabetes patients with elevated insulin resistance.

Journal of endocrinological investigation·2024
Same author

A global initiative to deliver precision health in diabetes.

Nature medicine·2024
Same author

Racial and ethnic differences among children with new-onset autoimmune Type 1 diabetes.

Diabetic medicine : a journal of the British Diabetic Association·2017
Same author

Dissecting heterogeneity in paediatric Type 1 diabetes: association of TCF7L2 rs7903146 TT and low-risk human leukocyte antigen (HLA) genotypes.

Diabetic medicine : a journal of the British Diabetic Association·2016
Same author

DPD epitope-specific glutamic acid decarboxylase (GAD)65 autoantibodies in children with Type 1 diabetes.

Diabetic medicine : a journal of the British Diabetic Association·2016
Same author

Immunogenetics of endocrine disorders.

Immunology today·2014

Area of Science:

  • Immunogenetics
  • Autoimmune Diseases
  • Diabetes Mellitus Genetics

Background:

  • Type 1A diabetes is an autoimmune disease influenced by genetic and environmental factors.
  • Human leukocyte antigen (HLA) alleles are the primary genetic contributors to autoimmune diabetes.
  • Research utilizing twin, family, and animal studies has been crucial in understanding the genetic basis of this condition.

Purpose of the Study:

  • To elucidate the genetic underpinnings of Type 1A diabetes.
  • To identify specific genetic markers associated with susceptibility and resistance.
  • To explore the roles of both HLA and non-HLA genes in disease etiology.

Main Methods:

  • Analysis of human leukocyte antigen (HLA) alleles and haplotypes.
  • Investigation of genetic polymorphisms in genes such as insulin (IDDM2) and cytotoxic T lymphocyte antigen-4 (CTLA-4).
  • Comparative risk assessment in monozygotic twins and HLA-identical siblings.

Main Results:

  • Specific HLA haplotypes (e.g., DQA1*0301-DQB1*0302, DQA1*0501-DQB1*0201) are strongly associated with Type 1A diabetes susceptibility.
  • Other HLA haplotypes (e.g., DQA1*0102-DQB1*0602) confer resistance, while some (e.g., DQA1*0401-DQB1*0402) are linked to high risk.
  • Non-HLA genes and potential environmental factors contribute to diabetes risk, as indicated by twin study data.

Conclusions:

  • Genetic susceptibility to Type 1A diabetes is complex, involving multiple HLA and non-HLA genes.
  • Identifying at-risk individuals and predicting associated disorders can be improved through genetic studies.
  • Further research is needed to fully understand the interplay of genetic and environmental factors in Type 1A diabetes progression.

Related Experiment Videos