Appetite is not influenced by a unique milk peptide: caseinomacropeptide (CMP)

The milk protein, caseinomacropeptide (CMP), is a predominant breakdown product of casein in the human stomach, and may aid in the regulation of food intake. Using a human feeding study design, this project assessed the effects of CMP on satiety and satiation by measuring the amount of food consumed at meal times and through subjective motivation to eat questionnaires. The following beverage treatments were prepared: 0.4% CMP solution, 2.0% CMP solution, vehicle alone, and water containing colorant and clouding agent. Twenty male and 32 female adults were enrolled into the study using a Latin Square randomization. Treatment beverages and ad libitum lunches were consumed on four separate occasions at the Study Center. After lunch, subjects left the Study Center, and completed a standardized questionnaire every hour throughout the afternoon and evening to assess hunger and stomach fullness, and kept track of all food and beverages consumed. Under these experimental conditions, CMP had no effect on energy intake or weight of food consumed at lunch or for the remainder of the day. CMP also had no effect on subjective indicators of satiety. Intake of CMP before a midday meal has no effect on regulation of food intake over a short-term period.