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Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
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Regulation of gene expression by GC-rich DNA cis-elements

J P Hapgood1, J Riedemann, S D Scherer

  • 1Department of Biochemistry, Stellenbosch University, Stellenbosch 7602, South Africa. JHap@maties.sun.ac.za

Cell Biology International
|March 10, 2001
PubMed

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Transcriptional regulators bind to specific cis-regulatory sequences in the DNA to regulate gene transcription. These cis-regulatory sequences are very short, usually less than ten nucleotide pairs in length. The short length means that there is a high probability of the exact same sequence randomly occurring throughout the genome.  Since regulators can also bind to groups of similar sequences, this further increases the chances of random binding. Transcriptional regulators form dimers that...
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