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The many faces of the tumor suppressor gene APC
J H van Es1, R H Giles, H C Clevers
1Department of Immunology and Center for Biomedical Genetics, University Medical Center, Utrecht, 3508 GA, The Netherlands. J.vanEs@azu.nl
Abstract:
Inactivation of the tumor suppressor adenomatous polyposis coli (APC) protein is a critical early step in the development of familial and sporadic colon cancer. Close examination of the function of APC has shown that it is a multifunctional protein involved in a wide variety of processes, including regulation of cell proliferation, cell migration, cell adhesion, cytoskeletal reorganization, and chromosomal stability. Tantalizing clues to the different functions of APC have been provided by the identification of proteins interacting with several discrete motifs within APC. Each of these putative functions could link APC inactivation with tumorigenesis. Here, we will summarize recent findings regarding the diverse role of APC. We will emphasize the interaction of APC with different binding partners, the role of these complex interactions for normal functioning of the cell, and how disruption of these interactions may play a role in tumor development. The rapid progress made recently shows the many faces of APC, leading to a constant reappreciation of this multitasking tumor suppressor protein.
Insights
Inactivation of the adenomatous polyposis coli (APC) tumor suppressor is key in colon cancer. APC
Area of Science:
- Molecular Biology
- Oncology
- Cell Biology
Background:
- Inactivation of the adenomatous polyposis coli (APC) protein is a critical early step in the development of familial and sporadic colon cancer.
- APC is a multifunctional protein regulating cell proliferation, migration, adhesion, cytoskeletal organization, and chromosomal stability.
Purpose of the Study:
- To summarize recent findings on the diverse roles of the APC protein.
- To emphasize APC's interactions with binding partners and their role in normal cell function and tumor development.
Main Methods:
- Review of recent findings on APC protein interactions.
- Analysis of the functional consequences of APC binding partner interactions.
Main Results:
- APC interacts with various proteins through discrete motifs, suggesting diverse functions.
- These interactions are crucial for normal cellular processes.
- Disruption of APC interactions is implicated in tumor development.
Conclusions:
- APC is a multitasking tumor suppressor protein with diverse roles.
- Understanding APC's interactions is key to comprehending its role in colon cancer and developing therapeutic strategies.