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3Dee: a database of protein structural domains.

A S Siddiqui1, U Dengler, G J Barton

  • 1University of Oxford, Laboratory of Molecular Biophysics, The Rex Richards Building, South Parks Road, Oxford OX1 3QU, UK.

Bioinformatics (Oxford, England)
|March 10, 2001
PubMed
Summary

The 3Dee database provides a comprehensive repository for protein structural domains. It organizes domain information hierarchically and offers non-redundant sequence and structure sets for research.

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Area of Science:

  • Structural Biology
  • Bioinformatics

Background:

  • The 3Dee database serves as a centralized repository for protein structural domain information.
  • It is accessible online at http://barton.ebi.ac.uk/servers/3Dee.html.

Purpose of the Study:

  • To present the structure and content of the 3Dee database.
  • To highlight its utility in organizing and accessing protein domain data.

Main Methods:

  • The database integrates and organizes protein domain definitions.
  • It establishes hierarchical relationships based on sequence and structure.
  • Non-redundant sets of sequences and structures are curated.

Main Results:

  • 3Dee stores alternative domain definitions for proteins.

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  • Domains are organized into sequence and structural hierarchies.
  • Multiple structure alignments for domain families are included.
  • The database allows regeneration of previous versions.
  • Conclusions:

    • 3Dee offers a valuable resource for researchers studying protein domain organization.
    • Its comprehensive data and hierarchical structure facilitate structural biology and bioinformatics research.