Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

ODS2: a multiplatform software application for creating integrated physical and genetic maps.

D Hall1, S M Bhandarkar, J Wang

  • 1Department of Computer Science, The University of Georgia, Athens, Georgia 30602-7404, USA.

Genetics
|March 10, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pregnant patients with severe headaches - don't forget brain tumours!

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2025
Same author

Nasal hamartoma causing stenosis and partial obstruction in a Siamese cat.

Australian veterinary journal·2025
Same author

Retention in primary care among unstably housed residents of a low-income, inner-city neighborhood with a high prevalence of substance use and related disorders.

International journal for equity in health·2024
Same author

Principal Accompaniment in Australian Faith-Based Schools: A Salutogenesis Approach.

Journal of religion and health·2024
Same author

Publisher Correction: Live-cell three-dimensional single-molecule tracking reveals modulation of enhancer dynamics by NuRD.

Nature structural & molecular biology·2023
Same author

Live-cell three-dimensional single-molecule tracking reveals modulation of enhancer dynamics by NuRD.

Nature structural & molecular biology·2023

This study introduces ODS2, a Java software for creating accurate physical contig maps by integrating clone hybridization data with genetic map anchoring. ODS2 minimizes errors in clone ordering for genomic research.

Area of Science:

  • Genomics
  • Bioinformatics
  • Computational Biology

Background:

  • Physical maps are crucial for genome assembly, but errors in clone ordering arise from hybridization inaccuracies and library gaps.
  • Anchoring clones to existing genetic maps can resolve ambiguities in physical contig map construction.

Purpose of the Study:

  • To present ODS2, a novel software application for constructing physical contig maps.
  • To improve the accuracy of contig map generation by integrating clone-clone hybridization data with genetic map information.

Main Methods:

  • ODS2 utilizes clone-clone hybridization data and partial ordering information from genetic map anchorage.
  • A clone ordering algorithm processes this integrated data, with results visualized graphically for interactive alignment of physical and genetic maps.

Related Experiment Videos

  • The software features a graphical user interface, is implemented in Java for cross-platform compatibility, and supports local files or relational databases.

    • Main Results:

    • ODS2 enables interactive alignment of physical and genetic maps, reducing errors in clone order determination.
    • The software facilitates the creation of both full and minimum tiling contig maps.
    • Its Java implementation ensures broad accessibility across different operating systems.

    Conclusions:

    • ODS2 provides a robust and user-friendly solution for accurate physical contig map construction.
    • The integration of genetic map data significantly enhances the reliability of contig mapping, particularly for complex genomes.
    • ODS2 is a valuable tool for genomic research, aiding in genome assembly and comparative genomics.