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Glucagon-like peptide 2: a nutrient-responsive gut growth factor.
D G Burrin1, Y Petersen, B Stoll
1U.S. Department of Agriculture/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA. dburrin@bcm.tmc.edu
The Journal of Nutrition
|March 10, 2001
Summary
Glucagon-like peptide 2 (GLP-2) promotes intestinal growth and function. This peptide shows promise as a therapeutic for infants with gut issues, aiding neonatal gut development.
Area of Science:
- Gastroenterology
- Endocrinology
- Developmental Biology
Background:
- Glucagon-like peptide 2 (GLP-2) is a peptide hormone produced in the gut.
- Its secretion is stimulated by nutrient intake.
- GLP-2 activity is regulated by dipeptidylpeptidase IV.
Purpose of the Study:
- To investigate the role of GLP-2 in intestinal development and function.
- To explore the potential therapeutic applications of GLP-2 in neonatal gut disorders.
Main Methods:
- Review of existing studies on GLP-2.
- Analysis of GLP-2's effects on cell proliferation, apoptosis, and proteolysis in the intestine.
- Examination of GLP-2 receptor (GLP-2R) expression and function.
Main Results:
- GLP-2 exhibits trophic effects on the small and large intestines by promoting cell proliferation and inhibiting apoptosis.
- GLP-2 influences gastric motility, acid secretion, and food intake.
- GLP-2 and its receptor are present in the fetus, but the intestine only becomes responsive postnatally.
Conclusions:
- GLP-2 plays a significant role in intestinal growth and development.
- Its efficacy in preventing neonatal gut atrophy suggests potential as a therapeutic adjuvant for infants with compromised gut function.