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Updated: Aug 11, 2026
11:28
Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus
Published on: October 7, 2011
Molecular pathways in virus-induced cytokine production
1Department of Medical Microbiology and Immunology, University of Aarhus, DK-8000 Aarhus C, Denmark.
Microbiology and Molecular Biology Reviews : MMBR
|March 10, 2001
Summary
Virus infections trigger inflammation and immune cell responses. This review details how viruses activate signaling pathways, like NF-kappaB, to express immune-signaling molecules and fight infection.
Area of Science:
- Immunology
- Virology
- Molecular Biology
Background:
- Virus infections elicit a proinflammatory response crucial for host defense.
- This response involves cytokine and chemokine expression, leading to leukocyte recruitment.
- Molecular interactions between viruses and host cells initiate these critical defense mechanisms.
Purpose of the Study:
- To review current knowledge on virus-induced signal transduction pathways.
- To analyze the molecular mechanisms of cytokine and chemokine expression during viral infections.
- To discuss signaling in seven human pathogenic viruses and common experimental models.
Main Methods:
- Review of existing literature on virus-induced signaling.
- Analysis of molecular interactions initiating host responses.
- Examination of transcription factor activation, particularly NF-kappaB.
Main Results:
- Viral components (glycoproteins, dsRNA, intracellular proteins) activate signaling pathways.
- Major proinflammatory pathways, including NF-kappaB, are activated by viruses.
- Activated transcription factors regulate host and viral gene expression.
Conclusions:
- Virus-cell interactions are key to initiating antiviral inflammatory responses.
- Understanding these signaling pathways is vital for comprehending host defense against viruses.
- This review consolidates knowledge on virus-induced immune signaling.
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