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Coping with grim news from genetic tests.

M Horowitz¹, E Sundin, A Zanko

¹Department of Psychiatry, University of California in San Francisco 94143, USA.

|March 10, 2001

Summary

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Genetic testing for inherited disease susceptibility can trigger stress response syndromes. Psychotherapy may be necessary for patients experiencing severe psychological distress beyond standard genetic counseling.

Area of Science:

Medical Genetics
Psychology
Clinical Medicine

Background:

Genetic testing for inherited susceptibility to serious diseases is increasingly common.
Patients receiving high-risk genetic test results may face significant psychological distress.
Standard genetic counseling may not adequately address all patient needs.

Purpose of the Study:

To highlight the importance of recognizing and managing stress response syndromes following genetic testing.
To emphasize the potential need for psychotherapy in addition to genetic counseling for some patients.

Main Methods:

This study is a review of clinical observations and existing literature on psychological responses to genetic testing.
It synthesizes information on the spectrum of stress responses and their management.

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Main Results:

High-risk genetic test results can precipitate a range of psychological symptoms, including denial, intrusive thoughts, and anxiety.
These stress responses can significantly impact patient well-being.
Genetic counseling alone may be insufficient for managing these psychological sequelae.

Conclusions:

Clinicians must be vigilant in identifying stress response syndromes post-genetic testing.
Psychological evaluation and psychotherapy are indicated for patients experiencing significant distress.
Integrated care addressing both genetic risk and psychological impact is crucial for patient well-being.