Related Experiment Video
Updated: Jun 21, 2026

Floral-Dip Transformation of Flax (Linum usitatissimum) to Generate Transgenic Progenies with a High Transformation Rate
Published on: December 19, 2014
Filopodial calcium transients promote substrate-dependent growth cone turning
1Department of Biology and Center for Molecular Genetics, University of California, San Diego, La Jolla, CA 92093, USA. tmgomez@facstaff.wisc.edu
Abstract:
Filopodia that extend from neuronal growth cones sample the environment for extracellular guidance cues, but the signals they transmit to growth cones are unknown. Filopodia were observed generating localized transient elevations of intracellular calcium ([Ca2+]i) that propagate back to the growth cone and stimulate global Ca2+ elevations. The frequency of filopodial Ca2+ transients was substrate-dependent and may be due in part to influx of Ca2+ through channels activated by integrin receptors. These transients slowed neurite outgrowth by reducing filopodial motility and promoted turning when stimulated differentially within filopodia on one side of the growth cone. These rapid signals appear to serve both as autonomous regulators of filopodial movement and as frequency-coded signals integrated within the growth cone and could be a common signaling process for many motile cells.
More Related Videos
Related Concept Videos
Morphogenesis
Gene Flow
Energy to Drive Translocation
Generally, polypeptides are unfolded by two distinct...
Microtubule Instability
Mechanism of Lamellipodia Formation
Horizontal Gene Transfer

