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Frosted branch angiitis in a child with HIV infection
H F Fine1, J A Smith, B L Murante
1Clinical Research Training Program, National Eye Institute, National Institutes of Health, MSC 1863, 10 Center Drive, 10/10N112, Bethesda, MD 20892-1863, USA. hfine@alum.mit.edu
Purpose:
In adults with human immunodeficiency virus (HIV) infection, frosted branch angiitis is commonly associated with cytomegalovirus retinitis and responds to anti-cytomegalovirus therapy. We describe the first pediatric case of HIV-associated frosted branch angiitis.
Methods:
Case report.
Results:
A 7-year-old HIV-infected male with frosted branch angiitis was refractory to induction doses of intravenous ganciclovir and foscarnet over a 2-month period. Although cytomegalovirus antigenemia resolved, the angiitis only improved after subsequent treatment with systemic corticosteroids.
Conclusion:
Frosted branch angiitis in this patient was not attributed to cytomegalovirus. The pathogenesis of HIV-associated frosted branch angiitis may differ between children and adults.