Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Complementary 'bottom-up' and 'top-down' approaches to basal ganglia function.

D J Perkel1, M A Farries

  • 1Department of Neuroscience, 215 Stemmler Hall, University of Pennsylvania, Philadelphia, PA 19104-6074, USA. perkel@u.washington.edu

Current Opinion in Neurobiology
|March 10, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Balance Hypothesis for the Avian Lumbosacral Organ and an Exploration of Its Morphological Variation.

Integrative organismal biology (Oxford, England)·2021
Same author

The oscine song system considered in the context of the avian brain: lessons learned from comparative neurobiology.

Brain, behavior and evolution·2002
Same author

An avian basal ganglia pathway essential for vocal learning forms a closed topographic loop.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2001
Same author

Slow synaptic inhibition mediated by metabotropic glutamate receptor activation of GIRK channels.

Journal of neurophysiology·2000
Same author

Electrophysiological properties of avian basal ganglia neurons recorded in vitro.

Journal of neurophysiology·2000
Same author

Sexual dimorphism in the song system of the Carolina wren Thryothorus ludovicianus.

The Journal of comparative neurology·2000

New research highlights basal ganglia function using distinct

Area of Science:

  • Neuroscience
  • Cellular Biology
  • Systems Neuroscience

Background:

  • Basal ganglia play a crucial role in motor control and learning.
  • Parkinsonian tremor is associated with abnormal low-frequency bursting in basal ganglia nuclei.
  • Understanding basal ganglia circuitry is key to addressing neurological disorders.

Purpose of the Study:

  • To investigate basal ganglia function using novel 'bottom-up' and 'top-down' approaches.
  • To identify neural circuits involved in avian song learning within the basal ganglia.
  • To explore the role of specific basal ganglia nuclei in generating pathological activity.

Main Methods:

  • Utilizing organotypic co-cultures for in vitro studies.
  • Investigating avian song learning circuits.

Related Experiment Videos

  • Analyzing cellular and circuit-level activity in basal ganglia models.

    • Main Results:

    • The subthalamic nucleus (STN) and external globus pallidus (GP(e)) identified as potential pacemakers for Parkinsonian tremor-like activity.
    • A conserved basal ganglia circuit essential for avian song learning was identified.
    • Cellular details within the avian song system show remarkable conservation.

    Conclusions:

    • The STN and GP(e) may be critical in generating abnormal oscillatory activity seen in Parkinsonian tremor.
    • Avian song learning provides a valuable model system for understanding general basal ganglia function.
    • Conserved cellular mechanisms in the basal ganglia offer insights into diverse functions.