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[Pyoderma gangrenosum. 15 cases].

I Riahi¹, M Mokni, S Haouet

¹Service de Dermatologie, Hôpital de La Rabta, Bab Saadoun, Tunis, Tunisie.

Annales De Medecine Interne

|March 10, 2001

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This study of 15 pyoderma gangrenosum cases found leg ulcers common, often with internal diseases. Neutrophilic pneumopathy occurred, proving rapidly fatal in two patients.

Area of Science:

Dermatology
Internal Medicine
Pathology

Background:

Pyoderma gangrenosum (PG) is a rare, chronic, ulcerative skin condition.
Understanding its varied presentations and associations is crucial for patient management.

Observation:

A retrospective review of 15 PG cases was conducted.
The male/female ratio was 2:1, with an average age of 40.
Common forms included typical ulcerous (11 cases), bullous (2), and granulomatous superficial (2).
The leg was the most frequent site, often with other skin involvements.
Two patients presented with neutrophilic pulmonary involvement concurrent with skin ulcers.
Eight patients had associated internal diseases.

Findings:

Histological analysis revealed vasculitis in 11 patients, with leukocytoclastic vasculitis in 9.

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Prednisone and clofazimine were the most common treatments.

The recurrence rate for pyoderma gangrenosum was 46%, irrespective of treatment.

Neutrophilic pneumopathy was a rapidly fatal complication in two patients.

Implications:

This study highlights the diverse clinical spectrum of pyoderma gangrenosum.
The frequent association with internal diseases and vasculitis underscores the need for comprehensive patient evaluation.
The high recurrence rate and potential for fatal pulmonary complications emphasize the severity and complexity of managing PG.