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Related Experiment Videos

Rare side-effects of fenofibrate.

R Rabasa-Lhoret1, M Rasamisoa, A Avignon

  • 1Service des Maladies Métaboliques, Hôpital Lapeyronie, Centre Hospitalier Universitaire de Montpellier, 34295 Montpellier Cedex 05. rrabasa@mnet.fr

Diabetes & Metabolism
|March 10, 2001
PubMed
Summary

This case report details a rare, severe allergic reaction to fenofibrate, a common lipid-lowering drug. The patient experienced fever and pancytopenia, which resolved after discontinuing the medication.

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Area of Science:

  • Pharmacology
  • Clinical Toxicology
  • Internal Medicine

Background:

  • Fibrates, including fenofibrate, are frequently prescribed for dyslipidemia and generally considered safe.
  • Hypolipidemic agents play a crucial role in managing cardiovascular risk factors.
  • Adverse drug reactions, though uncommon, necessitate careful monitoring in clinical practice.

Observation:

  • A 69-year-old woman experienced asthenia, high fever (40.5°C), and myalgia after starting generic fenofibrate 300 mg daily.
  • Biological findings included elevated muscle enzymes and rapid onset pancytopenia.
  • Extensive investigations ruled out infectious, autoimmune, and other etiologies.

Findings:

  • This is the first reported instance of major fever and pancytopenia linked to fenofibrate therapy.

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  • The patient's symptoms and laboratory abnormalities resolved spontaneously upon fenofibrate withdrawal.
  • Fenofibrate-induced hypersensitivity reactions, though rare, can manifest with significant hematological and systemic effects.

    • Implications:

    • This case highlights the potential for severe, idiosyncratic reactions to fenofibrate, even in its generic form.
    • Clinicians should maintain a high index of suspicion for drug-induced pancytopenia in patients presenting with unexplained fever and cytopenias.
    • Prompt drug discontinuation is crucial for favorable outcomes in managing fenofibrate-induced adverse events.