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[Effect of fluoxetine on histamine content in the rat conjunctiva]
1Département de Pharmacologie Expérimentale, Faculté de Médecine, Université d'Athènes, M. Asias 75, GR-11527 Athènes, Grèce.
Purpose:
To determine the histamine levels of the rat conjunctiva following local administration of fluoxetine, a selective serotonin uptake inhibitor.
Materials And Methods:
Basal histamine and amine levels were determined in the rat conjunctiva following local application of compound 48/80. Fluoxetine was administered in the conjunctival fornix of the left eye of the rat, whereas the right eye, serving as control, received a drop of vehicle. After one hour, the conjunctiva was removed and homogenized, and the tissue histamine content was quantified fluorometrically.
Results:
Histamine levels reached 149.6%+/-11.6 of the control eye after local administration of fluoxetine. This increase was statistically significant (p<0.004) compared to the control. Simultaneous application of the histamine releaser compound 48/80 re-established normal histamine levels in the conjunctiva.
Conclusion:
It can be postulated that the selective serotonin uptake inhibitors play an important role in the histamine concentration of the conjunctiva and in its variations.