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Predicting response to neoadjuvant chemotherapy in patients with cervical carcinoma: can we do without any longer?
E. T. M. De Jonge1, B. G. Lindeque, W. Burger
1Department of Obstetrics and Gynecology, Kalafong Academic Hospital, University of Pretoria, South Africa;Department of Medical Oncology, Pretoria Academic Hospital, University of Pretoria, South Africa;Department of Pathology, The Norwegian Radium Hospital, University of Oslo, Oslo, Norway.
Abstract:
The aim of the study was to identify variables that may predict the response to neoadjuvant chemotherapy (NACT) in patients with cervical cancer as maturing data from the literature indicate that this therapeutic strategy might be beneficial to some but harmful to others. Clinico-pathologic variables including age, histology, tumor differentiation, as well as immunohistochemical overexpression of p53, mdm2, c-erbB-2, and cathepsin D in 37 of these patients were evaluated as possible predictors of response to the NACT. Fifty-five patients with stage IIB cervical cancer submitted to two courses of cisplatin/ifosfamide/mesna prior to definitive treatment with radical surgery or radiation therapy were the subjects of this study. The clinical response rate was 80% but none of the variables was able to predict response to NACT. Unless methods are found enabling us to predict response and therefore to identify those patients that could benefit from including NACT in the treatment of locally advanced cervical cancer, only women with primarily resectable tumors should be selected for this multimodality approach as a result of the possibility of cross-resistance with radiation therapy in nonresponders.