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Related Experiment Videos

Angiogenesis in the uterine cervix.

O. Abulafia1, D. M. Sherer

  • 1Department of Obstetrics and Gynecology, State University of New York at Brooklyn, Brooklyn, New York and the Department of Obstetrics and Gynecology, St. Luke's Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, New York.

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
|March 10, 2001
PubMed
Summary

Angiogenesis, the growth of new blood vessels, is key in cervical cancer development and progression. Anti-angiogenic therapies show promise for advanced cervical cancers.

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Area of Science:

  • Gynecologic Oncology
  • Vascular Biology
  • Cancer Research

Background:

  • Angiogenesis plays a vital physiological role in the ovary and endometrium during the menstrual cycle.
  • In the uterine cervix, angiogenesis is predominantly linked to neoplastic processes rather than normal physiological functions.

Purpose of the Study:

  • To review current data on the role of angiogenesis in the uterine cervix.
  • To explore the association between cervical angiogenesis and various neoplastic conditions, including intraepithelial neoplasia and invasive carcinomas.

Main Methods:

  • A comprehensive computerized literature search was performed.
  • Databases searched included MEDLINE, Current Contents, and Index Medicus.
  • Keywords used were: angiogenesis, uterine cervix, intraepithelial neoplasia, squamous cell carcinoma, and adenocarcinoma (1966-June 1999).

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Main Results:

  • Cervical angiogenesis is primarily involved in neoplastic diseases like intraepithelial neoplasia and squamous cell/adenocarcinoma.
  • In invasive cervical cancers, angiogenesis serves as a prognostic indicator for overall and disease-free survival.
  • Early trials of anti-angiogenic therapy (e.g., TNP-470) demonstrated antitumor activity in advanced cervical cancer patients.

Conclusions:

  • Angiogenesis is a critical factor in the pathogenesis and progression of cervical cancer.
  • The extent of angiogenesis correlates with patient survival outcomes in invasive cervical cancer.
  • Anti-angiogenic therapies represent a potential treatment strategy for advanced cervical malignancies.